Small islands in the Mediterranean Sea, although endowed with exquisite land and maritime natural and cultural resources, are in most cases lagging behind areas, mainly due to insularity.Through their long history, many of them are strongly interwoven to events of European or even global significance, e.g., World War (WW) I and II.Such events have
Remifentanil has a unique pharmacokinetic profile, with a rapid onset and offset of action and a plasmatic metabolism.Its use can be recommended even in patients with renal impairment, hepatic dysfunction or poor cardiovascular function.A potential protective cardiac preconditioning effect has been suggested.Drug-related adverse Baby Toothpaste eff
Objective: Melanocortin 2 receptor accessory protein 2 (MRAP2) has a critical role in energy homeostasis.Although MRAP2 has been shown to regulates a number of GPCRs involved in metabolism, the key neurons responsible for the phenotype of gross obesity in MRAP2 deficient animals are unclear.Furthermore, Cooler to date, all the murine MRAP2 models i
First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein NUTRI SEA OMEGA 3 HP+D microarray (PM) technologies.Here, we developed a large-scale fluorescence polarization (FP) methodology that was able to characterize interactions between SH2 domains